We surveyed the transcriptome of duodenal probes from 25 children with active Coeliac Disease and 21 children without CD but with diverse intestinal afflictions as controls. We found that Transcriptomic CD samples could be divided in 3 subgroups: Mixed, CD-Low and CD-High. Samples of the Mixed group showed highest similarity to non-CD samples.
Our findings show that multiple pathways appear in diverse signal power and variation in CD also on transcriptomic level in a multifaceted way.
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Accompanying publication is available <a href="https://pubmed.ncbi.nlm.nih.gov/33806322/", target="_blank">here</a>.